Oncovirology

What is an oncovirus? Viruses that can cause cancer

What an oncovirus is

An oncovirus (or oncogenic virus) is a virus capable of inducing or contributing to the development of cancer in the cells it infects, usually by altering the normal cell cycle or interfering with the mechanisms that control cell growth. Not every infected person develops cancer: other factors (genetic, environmental, immune) also play a role.

Human oncoviruses recognized by IARC-WHO

HPV (human papillomavirus)

Cervical, anal, penile and oropharyngeal cancer

Epstein-Barr virus (EBV)

Burkitt lymphoma, nasopharyngeal carcinoma, some lymphomas and gastric cancers

Hepatitis B and C viruses

Liver cancer (hepatocellular carcinoma)

HTLV-1

Adult T-cell leukemia/lymphoma

Kaposi sarcoma-associated herpesvirus (HHV-8)

Kaposi sarcoma

Merkel cell polyomavirus (MCPyV)

Merkel cell carcinoma, a rare skin cancer

Why it matters to know them

Early detection of the infection, vaccination (when available, as with HPV) and proper medical follow-up can significantly reduce the risk of a viral infection progressing to cancer.